Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications

G Lambrecht - Naunyn-Schmiedeberg's archives of pharmacology, 2000 - Springer
P2X receptors are nucleotide-gated cation channels composed of homomeric or
heteromeric assemblies of three subunits. In the past 7 years, an extended series (P2X 1–7) …

Specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates

A Guranowski - Pharmacology & therapeutics, 2000 - Elsevier
This review concerns enzymes that can degrade nucleoside 5′-tetra-and pentaphosphates
(p4N and p5N) and those that can degrade various dinucleoside polyphosphates (Np3 …

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons

M Díaz-Hernandez, A del Puerto… - Journal of cell …, 2008 - journals.biologists.com
During the establishment of neural circuits, the axons of neurons grow towards their target
regions in response to both positive and negative stimuli. Because recent reports show that …

Overexpression of P2X3 and P2X7 receptors and TRPV1 channels in adrenomedullary chromaffin cells in a rat model of neuropathic pain

M Arribas-Blázquez, LA Olivos-Oré… - International Journal of …, 2019 - mdpi.com
We have tested the hypothesis that neuropathic pain acting as a stressor drives functional
plasticity in the sympathoadrenal system. The relation between neuropathic pain and …

The effects of diadenosine polyphosphates on the cardiovascular system

NA Flores, BM Stavrou, DJ Sheridan - Cardiovascular research, 1999 - academic.oup.com
Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that
are ubiquitous, naturally occurring molecules. They form a recently identified class of …

Diadenosine polyphosphate receptors: from rat and guinea-pig brain to human nervous system

J Pintor, M Dı́az-Hernández, J Gualix… - Pharmacology & …, 2000 - Elsevier
Diadenosine polyphosphates are a family of naturally occurring nucleotidic compounds
present in secretory vesicles together with other chemical messengers. The exocytotic …

Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors

BF King, M Liu, J Pintor, J Gualix… - British journal of …, 1999 - Wiley Online Library
The antagonist activity of a series of diinosine polyphosphates (IpnI, where n= 3, 4, 5) was
assessed against ATP‐activated inward currents at rat P2X1–4 receptors expressed in …

Nucleotides in the eye: focus on functional aspects and therapeutic perspectives

A Guzman-Aranguez, C Santano, A Martin-Gil… - … of Pharmacology and …, 2013 - ASPET
The presence and activity of nucleotides and dinucleotides in the physiology of most, if not
all, organisms, from bacteria to humans, have been recognized by the scientific community …

Glutamate release and synapsin-I phosphorylation induced by P2X7 receptors activation in cerebellar granule neurons

D León, J Sánchez-Nogueiro, P Marín-García… - Neurochemistry …, 2008 - Elsevier
The present work reports that activation of P2X7 receptor induces synaptic vesicle release in
granule neurons and phosphorylation of synapsin-I by calcium–calmodulin-dependent …

Co-localisation of functional nicotinic and ionotropic nucleotide receptors in isolated cholinergic synaptic terminals

M Dı́az-Hernández, J Pintor, E Castro… - …, 2002 - Elsevier
The combination of immunological and microfluorimetric techniques has permitted the
identification and analysis of the Ca2+ influx responses in single rat midbrain cholinergic …