Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
Aging hallmarks and the role of oxidative stress
E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …
function of the organism and an increased risk of age-related chronic diseases such as …
Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …
associated with the erosion of chromatin organization at the nuclear periphery. However …
[HTML][HTML] Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging …
O Demidenko, D Barardo, V Budovskii… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The search continues for possible interventions that delay and/or reverse biological aging,
resulting in extended healthspan and lifespan. Interventions delaying aging in animal …
resulting in extended healthspan and lifespan. Interventions delaying aging in animal …
Ranking biomarkers of aging by citation profiling and effort scoring
A Hartmann, C Hartmann, R Secci, A Hermann… - Frontiers in …, 2021 - frontiersin.org
Aging affects most living organisms and includes the processes that reduce health and
survival. The chronological and the biological age of individuals can differ remarkably, and …
survival. The chronological and the biological age of individuals can differ remarkably, and …
[HTML][HTML] ARDD 2020: from aging mechanisms to interventions
GV Mkrtchyan, K Abdelmohsen, P Andreux… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …
investors. New technologies such as artificial intelligence and advanced screening …
[HTML][HTML] Pathogenic mitochondrial dysfunction and metabolic abnormalities
Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …
diseases to set the stage for new therapeutic advances. Cellular and acellular …
Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan
We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …
Uterine microbial communities and their potential role in the regulation of epithelium cell cycle and apoptosis in aged hens
D Dai, J Wang, H Zhang, S Wu, G Qi - Microbiome, 2023 - Springer
Background Alterations of the uterine microbiome are closely associated with various
intrauterine diseases and physiological conditions, which are well-established in mammals …
intrauterine diseases and physiological conditions, which are well-established in mammals …
[HTML][HTML] Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions
Y Lin, C Lin, Y Cao, Y Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Natural antioxidants have recently emerged as a highly exciting and significant topic in anti-
aging research. Diverse organism models present a viable protocol for future research …
aging research. Diverse organism models present a viable protocol for future research …