Antibody drug conjugate: the “biological missile” for targeted cancer therapy

Z Fu, S Li, S Han, C Shi, Y Zhang - Signal transduction and targeted …, 2022 - nature.com
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs)
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …

Emerging new therapeutic antibody derivatives for cancer treatment

S Jin, Y Sun, X Liang, X Gu, J Ning, Y Xu… - Signal transduction and …, 2022 - nature.com
Monoclonal antibodies constitute a promising class of targeted anticancer agents that
enhance natural immune system functions to suppress cancer cell activity and eliminate …

Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Exploring the next generation of antibody–drug conjugates

K Tsuchikama, Y Anami, SYY Ha… - Nature Reviews Clinical …, 2024 - nature.com
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

Antibody–drug conjugates: A review of approved drugs and their clinical level of evidence

P Gogia, H Ashraf, S Bhasin, Y Xu - Cancers, 2023 - mdpi.com
Simple Summary Antibody–drug conjugates (ADC) have shown remarkable therapeutic
activity in a wide range of hematologic and solid tumors. Herein, we discuss the …

[HTML][HTML] A comprehensive review of key factors affecting the efficacy of antibody drug conjugate

A Samantasinghar, NP Sunildutt, F Ahmed… - Biomedicine & …, 2023 - Elsevier
Abstract Antibody Drug Conjugate (ADC) is an emerging technology to overcome the
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …

Targeting cancer with antibody-drug conjugates: Promises and challenges

AQ Dean, S Luo, JD Twomey, B Zhang - MAbs, 2021 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …

Antibody-drug conjugates in lung cancer: dawn of a new era?

N Coleman, TA Yap, JV Heymach… - npj Precision …, 2023 - nature.com
Antibody-drug conjugates (ADCs) are one of fastest growing classes of oncology drugs in
modern drug development. By harnessing the powers of both cytotoxic chemotherapy and …

Drug conjugate-based anticancer therapy-Current status and perspectives

Y Yang, S Wang, P Ma, Y Jiang, K Cheng, Y Yu… - Cancer Letters, 2023 - Elsevier
Drug conjugates are conjugates comprising a tumor-homing carrier tethered to a cytotoxic
agent via a linker that are designed to deliver an ultra-toxic payload directly to the target …

Advances and limitations of antibody drug conjugates for cancer

CM Mckertish, V Kayser - Biomedicines, 2021 - mdpi.com
The popularity of antibody drug conjugates (ADCs) has increased in recent years, mainly
due to their unrivalled efficacy and specificity over chemotherapy agents. The success of the …