Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis,
and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate …

Low-voltage-activated T-type Ca2+ channels contribute to a wide variety of physiological
functions, most predominantly in the nervous, cardiovascular and endocrine systems …

BACKGROUND AND PURPOSE Endostatin (ES) is ac‐terminal proteolytic fragment of
collagen XVIII with promising antitumour properties in several tumour models, including …

Background Adipokines, including adiponectin, are implicated in nociceptive pain; however,
the underlying cellular and molecular mechanisms remain unknown. Methods Using …

G-protein–coupled receptors (GPCRs) are essential for the detection of extracellular stimuli
by cells and transfer the encoded information via the activation of functionally distinct …

The arcuate nucleus (ARC) of the hypothalamus plays a key role in pain processing.
Although it is well known that inhibition of NMDA receptor (NMDAR) in ARC attenuates …

This paper is the thirty-fourth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2011 …

Although brain-derived neurotrophic factor (BDNF) is implicated in the nociceptive signaling
of peripheral sensory neurons, the underlying mechanisms remain largely unknown. Here …

Cancer is a debilitating disease that is on the increase in both developed and developing
countries. Anticancer drugs are often expensive, have narrow spectrum of activities, and are …

Abstract Background Interleukin 24 (IL-24) has been implicated in the nociceptive signaling.
However, direct evidence and the precise molecular mechanism underlying IL-24's role in …