Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B
cells has proven to be a successful treatment for B cell malignancies. This success inspired …

Lung transplantation is the major surgical procedure, which restores normal lung functioning
and provides years of life for patients suffering from major lung diseases. Lung transplant …

HLA‐sensitized patients on the transplant waiting list harbor antibodies and memory B cells
directed against allogeneic HLA molecules, which decreases the chance to receive a …

Cytotoxic T lymphocyte has been a concern for the etiopathogenesis of alopecia areata
(AA), some recent evidence suggests that the regulatory T (Treg) cell deficiency is also a …

Background The administration of modified immune cells (MIC) before kidney
transplantation led to specific immunosuppression against the allogeneic donor and a …

For patients suffering from organ failure due to injury or autoimmune disease, allogeneic
organ transplantation with chronic immunosuppression is considered the gold standard in …

Balancing the immune response after solid organ transplantation (SOT) and vascularized
composite allotransplantation (VCA) remains an ongoing clinical challenge. While …

Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by
which the loss of peripheral tolerance leads to the development of autoimmunity and the …

The ability to induce tolerance would be a major advance in the field of solid organ
transplantation. Here, we investigated whether autologous (congenic) hematopoietic stem …