Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Dysregulated proteostasis is one of the hallmarks of ageing. Damaged proteins may impair
cellular function and their accumulation may lead to tissue dysfunction and disease. This is …

Ageing is defined as a time-dependent functional decline that occurs in most of live
organisms. Brain modification during the ageing process has been considered to …

The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control,
immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC …

The high substrate selectivity of the ubiquitin/proteasome system is mediated by a large
group of E3 ubiquitin ligases. The ubiquitin ligase CHIP regulates the degradation of …

The HECT (homologous to E6AP C-terminus) ubiquitin ligases (E3s) are a small family of
highly conserved enzymes involved in diverse cellular functions and pathological …

TRIpartite motif (TRIM) proteins are part of the largest subfamilies of E3 ligases that mediate
the transfer of ubiquitin to substrate target proteins. In this review, we focus on TRIM37 in the …

Diabetes is a global epidemic, of which type 2 diabetes makes up the majority of cases.
Nonetheless, for some individuals, type 2 diabetes is eminently preventable and treatable …

Melanoma is a type of cancer with a relatively poor prognosis. The development of
immunotherapy for the treatment of patients with melanoma has drawn considerable …

Proteolysis‐targeting chimeras (PROTACs) are novel therapeutics for the treatment of
human disease. They exploit the enormous potential of the E3 ligases, a class of proteins …