Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

Magnetic resonance imaging (MRI) contrast agents have become an important tool in
clinical medicine. The most common agents are Gd3+-based complexes that shorten bulk …

Metastasis is a multistep process that culminates in the spread of cells from a primary tumor
to a distant site or organs. For tumor cells to be able to metastasize, they have to locally …

Tumors are ecosystems which develop from stem cells endowed with unlimited self-renewal
capability and genetic instability, under the effects of mutagenesis and natural selection …

Cancer is a chronic disease that is responsible for the high death rate, globally. The
administration of anticancer drugs is one crucial approach that is employed for the treatment …

Magnetic resonance imaging (MRI) has inherent advantages in safety, three-dimensional
output, and clinical relevance when compared with optical and radiotracer imaging methods …

Tumor acidosis is a consequence of altered metabolism, which can lead to chemoresistance
and can be a target of alkalinizing therapies. Noninvasive measurements of the extracellular …

Biomedical imaging techniques can provide a vast amount of anatomical information,
enabling diagnosis and the monitoring of disease and treatment profile. MRI uniquely offers …

Solid tumors often develop an acidic environment due to the Warburg effect. The
effectiveness of diagnosis and therapy may therefore be enhanced by the design and use of …