Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
emerged as a novel means for sensitive detection of dilute labile protons and chemical …

pH is a fundamental physiological parameter that is tightly controlled by endogenous
buffers. The acid–base balance is altered in many disease states, such as inflammation …

The reduction/oxidation (redox) potential of tissue is tightly regulated in order to maintain
normal physiological processes, but is disrupted in disease states. Thus, the development of …

Here we present a “smart” xenon-129 NMR biosensor that undergoes a peptide
conformational change and labels cells in acidic environments. To a cryptophane host …

Dichloroacetate (DCA) can reverse the glycolytic phenotype that is responsible of increased
lactate production and extracellular pH acidification in cancer cells. Magnetic resonance …

The design of effective pH responsive MRI contrast agents is a key goal in the development
of new diagnostic methods for conditions such as kidney disease and cancer. A key factor …

The development of responsive or “smart” magnetic resonance imaging (MRI) contrast
agents that can report specific biomarker or biological events has been the focus of MRI …

Magnetic resonance imaging (MRI) has become one of the most important diagnosis tools
available in medicine. Typically MRI is not capable of sensing biochemical activities …

Tissue temperature is a fundamental physiological parameter that can provide insight into
pathological processes. The purpose of this study was to develop and characterize a novel …

Altered tissue temperature and/or pH is a common feature in pathological conditions, where
metabolic demand exceeds oxygen supply such as in tumors and following stroke …