Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer.
In recent years, numerous studies have reported the functions of cholesterol metabolism in …

Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

Deregulated cell proliferation is an established feature of cancer, and altered tumor
metabolism has witnessed renewed interest over the past decade, including the study of …

The gut bacterial community is involved in the metabolism of bile acids and short‐chain fatty
acids (SCFAs). Bile acids are involved in the absorption of fat and the regulation of lipid …

Colorectal cancer (CRC) is one of the most commonly occurring cancers worldwide.
Although several genetic alterations have been associated with CRC onset and …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …

There are a plethora of cancer causes and the road to fully understanding the
carcinogenesis process remains a dream that keeps changing. However, a list of role …

Mevalonate pathway is a highly conserved pathway that produces isoprenoids and
cholesterol, and it is often increased in cancer cells. Cholesterol, upstream metabolites …

Tumor cells show high avidity for cholesterol in order to support their inherent nature to
divide and proliferate. This results in the rewiring of cholesterol homeostatic pathways by …