Paramagnetic NMR data contain extremely accurate long-range information on
metalloprotein structures and, when used in the frame of integrative structural biology …

In the past two decades, drug candidates with a covalent binding mode have gained the
interest of medicinal chemists, as several covalent anticancer drugs have successfully …

Paramagnetic effects on the NMR spectra are known to encode information on structure,
electronic properties and dynamics hardly accessible with any other technique, especially in …

Fc mediated effector functions of antibodies play important roles in immunotherapies and
vaccine efficacy but assessing those functions in animal models can be challenging due to …

Polycationic polypeptides prompt the polycondensation of inorganic oxides, most notably of
silica. Hen egg-white lysozyme is a small polycationic protein that is quite conveniently used …

The comprehensive delineation of inherent dynamic motions embedded in proteins, which
can be crucial for their functional repertoire, is often essential yet remains poorly understood …

Arthropods from class Arachnida constitute a large and diverse group with over 100,000
described species, and they are sources of many proteins that have a direct impact on …

Understanding the fine structural details of inhibitor binding at the active site of
metalloenzymes can have a profound impact on the rational drug design targeted to this …

Macromolecular refinement is an optimization process that aims to produce the most likely
macromolecular structural model in the light of experimental data. As such, macromolecular …

Proteins are among the most versatile biomolecules exhibiting diverse structural and
dynamical variations directly linked to their multifaceted functionalities. Traditional NMR …