Diarrhoea induced by chemotherapy in cancer patients is common, causes notable
morbidity and mortality, and is managed inconsistently. Previous management guidelines …

Disturbed homeostasis of gut microbiota has been suggested to be closely associated with 5-
fluorouracil (5-Fu) induced mucositis. However, current knowledge of the overall profiles of 5 …

Colorectal cancer (CRC) remains one of the top cancers in the world. Although early
detection improves the survival rate to around 90%, late detection would mean the need to …

Camptothesome is an innovative nanovesicle therapeutic comprising the sphingomyelin-
derived camptothecin (CPT) lipid bilayer. In this work, we deciphered that Camptothesome …

New insights gained through the use of state-of-the-art technologies, including next-
generation sequencing, are starting to reveal that the association between the …

Adjuvant 5-fluorouracil (5-FU)-based chemotherapy, including FOLFOX (5-FU, leucovorin,
and oxaliplatin), is recommended for colorectal cancer. However, intestinal mucositis …

The harmful impact of xenobiotics on the environment and human health is being more
widely recognized; yet, inter-and intraindividual genetic variations among humans modulate …

Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is
characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it …

Background and Aims Intestinal mucositis is a frequently encountered side effect in
oncology patients undergoing chemotherapy. No well-established or up to date therapeutic …

Gut microbiota is the most diverse and complex biological ecosystem, which is estimated to
consist of greater than 5 million distinct genes and 100 trillion cells which are in constant …