Natural products, with remarkable chemical diversity, have been extensively investigated for
their anticancer potential for more than a half-century. The collective efforts of the community …

The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …

A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …

Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are
stress-responsive domains where many partner proteins accumulate. Here, we clarify the …

Akt is a central player in the signal transduction pathways activated in response to many
growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of …

The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid
receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of …

The interaction of nuclear pore proteins (Nups) with active genes can promote their
transcription. In yeast, some inducible genes interact with the nuclear pore complex both …

Acute promyelocytic leukemia (APL) is driven by a chromosomal translocation whose
product, the PML/retinoic acid (RA) receptor α (RARA) fusion protein, affects both nuclear …