The intron–exon architecture of many eukaryotic genes raises the intriguing question of
whether this unique organization serves any function, or is it simply a result of the spread of …

A major function of the mitogen-activated protein kinase (MAPK) pathways is to control
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …

The NS1 protein of influenza A virus (NS1A protein) is a multifunctional protein that counters
cellular antiviral activities and is a virulence factor. Its N-terminal RNA-binding domain binds …

Eukaryotic cells are equipped with a machinery charged with the responsibility of
transporting a vast number of molecules in and out of the nucleus in a rapid, accurate, and …

Importin-α is the nuclear import receptor that recognizes cargo proteins which contain
classical monopartite and bipartite nuclear localization sequences (NLSs), and facilitates …

In metazoa, assembly of spliceosomal U snRNPs requires nuclear export of U snRNA
precursors. Export depends upon the RNA cap structure, nuclear cap-binding complex …

Recent progress indicates that there are multiple pathways of nucleocytoplasmic transport
which involve specific targeting sequences, such as nuclear localization sequences (NLSs) …

Changes in protein phosphorylation represent a mechanism that is frequently employed by
cells to regulate transcription factor activity. In response to alterations in the extracellular …

The regulated process of protein import into the nucleus of a eukaryotic cell is mediated by
specific nuclear localization signals (NLSs) that are recognized by protein import receptors …

In eukaryotic cells, the movement of macromolecules between the nucleus and cytoplasm
occurs through the nuclear pore complex (NPC)—a large protein complex spanning the …