Thyroid hormone and cerebellar development
GW Anderson - The Cerebellum, 2008 - Springer
Thyroid hormone (TH) plays a key role in mammalian brain development. The developing
brain is sensitive to both TH deficiency and excess. Brain development in the absence of TH …
brain is sensitive to both TH deficiency and excess. Brain development in the absence of TH …
Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference
GGJM Kuiper, W Klootwijk, TJ Visser - Endocrinology, 2003 - academic.oup.com
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T4 to rT3 and of
T3 to 3, 3′-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine …
T3 to 3, 3′-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine …
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency
R Peeters, C Fekete, C Goncalves… - American Journal …, 2001 - journals.physiology.org
The goal of the present investigation was to analyze the types 2 (D2) and 3 (D3)
iodothyronine deiodinases in various structures within the central nervous system (CNS) in …
iodothyronine deiodinases in various structures within the central nervous system (CNS) in …
Regulation of type III iodothyronine deiodinase expression in human cell lines
MHA Kester, GGJM Kuiper, R Versteeg… - Endocrinology, 2006 - academic.oup.com
Type I iodothyronine deiodinase (D1) and type II iodothyronine deiodinase (D2) catalyze the
activation of the prohormone T4 to the active hormone T3; type III iodothyronine deiodinase …
activation of the prohormone T4 to the active hormone T3; type III iodothyronine deiodinase …
Thyroid hormone receptor activity in the absence of ligand: physiological and developmental implications
J Bernal, B Morte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: The transcriptional activity of the thyroid hormone receptors is modulated
by the ligand, T3, but they have also activity as aporeceptors, in the unliganded state …
by the ligand, T3, but they have also activity as aporeceptors, in the unliganded state …
Neonatal thyroid‐stimulating hormone and association with attention‐deficit/hyperactivity disorder
Background Normal brain development is dependent on maternal, fetal and neonatal thyroid
function. Measuring neonatal thyroid‐stimulating hormone (TSH) 48‐72 hours after birth …
function. Measuring neonatal thyroid‐stimulating hormone (TSH) 48‐72 hours after birth …
Maternal thyroid hormone trajectories during pregnancy and child behavioral problems
JJ Endendijk, HAA Wijnen, VJM Pop… - Hormones and behavior, 2017 - Elsevier
There is ample evidence demonstrating the importance of maternal thyroid hormones,
assessed at single trimesters in pregnancy, for child cognition. Less is known, however …
assessed at single trimesters in pregnancy, for child cognition. Less is known, however …
Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1
RP Peeters, A Hernandez, L Ng, M Ma… - …, 2013 - academic.oup.com
Thyroid hormone serves many functions throughout brain development, but the mechanisms
that control the timing of its actions in specific brain regions are poorly understood. In the …
that control the timing of its actions in specific brain regions are poorly understood. In the …
The implications of iodine and its supplementation during pregnancy in fetal brain development
M Puig-Domingo, L Vila - Current Clinical Pharmacology, 2013 - ingentaconnect.com
Iodine is an essential trace element for life. Its biological effects are a consequence of its
incorporation to the thyroid hormones, which play a crucial role in fetal organogenesis, and …
incorporation to the thyroid hormones, which play a crucial role in fetal organogenesis, and …
Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones …
V Somogyi, A Gyorffy, TJ Scalise, DS Kiss… - Nutrition research …, 2011 - cambridge.org
Controlling energy homeostasis involves modulating the desire to eat and regulating energy
expenditure. The controlling machinery includes a complex interplay of hormones secreted …
expenditure. The controlling machinery includes a complex interplay of hormones secreted …