Antiviral drug delivery system for enhanced bioactivity, better metabolism and pharmacokinetic characteristics
R Chen, T Wang, J Song, D Pu, D He, J Li… - International journal …, 2021 - Taylor & Francis
Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …
Biopolymer nanovehicles for oral delivery of natural anticancer agents
Cancer is the second leading cause of death throughout the world. Nature‐inspired
anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized …
anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized …
M2 Macrophage Hybrid Membrane‐Camouflaged Targeted Biomimetic Nanosomes to Reprogram Inflammatory Microenvironment for Enhanced Enzyme‐Thermo …
R Chen, J Yang, M Wu, D Zhao, Z Yuan… - Advanced …, 2023 - Wiley Online Library
Excessive inflammatory reactions caused by uric acid deposition are the key factor leading
to gout. However, clinical medications cannot simultaneously remove uric acid and eliminate …
to gout. However, clinical medications cannot simultaneously remove uric acid and eliminate …
Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application
Y Zheng, Y Huang, J Luo, X Peng, X Gui, G Liu… - Chinese Chemical …, 2024 - Elsevier
Biomacromolecules are attractive in biomedical applications as therapeutic agents and
potential drug carriers due to their natural active components, good biocompatibility, and …
potential drug carriers due to their natural active components, good biocompatibility, and …
Oral administration of natural polyphenol-loaded natural polysaccharide-cloaked lipidic nanocarriers to improve efficacy against small-cell lung cancer
X Xie, Y Li, D Zhao, C Fang, D He, Q Yang… - … , Biology and Medicine, 2020 - Elsevier
Oral administration shows good tolerance in patients. Botanic anticancer drugs without
serious side effects have attracted increased attention worldwide. However, oral delivery of …
serious side effects have attracted increased attention worldwide. However, oral delivery of …
Smart stimuli-responsive and mitochondria targeting delivery in cancer therapy
Y Huang, T Wang, Q Tan, D He, M Wu… - International Journal …, 2021 - Taylor & Francis
Dysfunction in the mitochondria (Mc) contributes to tumor progression. It is a major
challenge to deliver therapeutic agents specifically to the Mc for precise treatment. Smart …
challenge to deliver therapeutic agents specifically to the Mc for precise treatment. Smart …
Bioinspired platelet-like nanovector for enhancing cancer therapy via p-selectin targeting
S Wan, Y Wu, Q Fan, G Yang, H Hu, S Tima… - Pharmaceutics, 2022 - mdpi.com
Cancer is a major threat to the health of humans. Recently, various natural products
including curcumin (CCM) have attracted enormous interest for efficacious cancer therapy …
including curcumin (CCM) have attracted enormous interest for efficacious cancer therapy …
Biomimetic membrane-structured nanovesicles carrying a supramolecular enzyme to cure lung cancer
J Gu, Y Huang, Z Yan, D He, Y Zhang… - … applied materials & …, 2020 - ACS Publications
Platforms for enzyme delivery must simultaneously have plasma stability, high catalytic
activity, and low/no immunogenicity of the enzyme. Here, we designed a novel biomimetic …
activity, and low/no immunogenicity of the enzyme. Here, we designed a novel biomimetic …
A novel evodiamine amino derivative as a PI3K/AKT signaling pathway modulator that induces apoptosis in small cell lung cancer cells
T Wang, D Qi, X Hu, N Li, X Zhang, H Liu… - European Journal of …, 2021 - Elsevier
Evodiamine (EVO) was derivatized to a C10-amino derivative (EVA) using a two-step
method suitable for industrializing production. This method has advantages such as a short …
method suitable for industrializing production. This method has advantages such as a short …
Oral supramolecular nanovectors for dual natural medicine codelivery to prevent gastric mucosal lesion
Y Chen, M Zhang, H Zhao, Y Liu, T Wang, T Lei… - Nanoscale, 2022 - pubs.rsc.org
The oral administration of a single formulation loaded with more than one natural medicine
to treat chronic diseases has advantages such as convenience, effectiveness, and economy …
to treat chronic diseases has advantages such as convenience, effectiveness, and economy …