Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

Galanin in pituitary adenomas

E Grenbäck, P Bjellerup, E Wallerman, L Lundblad… - Regulatory peptides, 2004 - Elsevier
Tumor galanin content was measured in extracts from human pituitary adenomas using a
specific RIA method for monitoring human galanin. Twenty-two out of twenty-four tumors …

Galanin and its receptors in neurological disorders

L Lundström, A Elmquist, T Bartfai, Ü Langel - Neuromolecular medicine, 2005 - Springer
Galanin is a highly inducible neuropeptide, showing distinct up-regulation after pathological
disturbance within the nervous system. Significant increase in galanin expression is …

The galaninergic system: A target for cancer treatment

ML Sánchez, R Coveñas - Cancers, 2022 - mdpi.com
Simple Summary Peptidergic systems play an important role in cancer progression. The
galaninergic system (the peptide galanin and its receptors: galanin 1, 2 and 3) is involved in …

Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells

A Berger, R Lang, K Moritz, R Santic, A Hermann… - …, 2004 - academic.oup.com
Recently we have shown that galanin binding significantly correlates with survival in
neuroblastoma patients, indicating a possible modulatory role of galanin receptors in …

Biomarker discovery for immunotherapy of pituitary adenomas: enhanced robustness and prediction ability by modern computational tools

Q Yang, Y Wang, S Zhang, J Tang, F Li, J Yin… - International Journal of …, 2019 - mdpi.com
Pituitary adenoma (PA) is prevalent in the general population. Due to its severe
complications and aggressive infiltration into the surrounding brain structure, the effective …

Galanin in the regulation of the hypothalamic-pituitary-adrenal axis

C Tortorella, G Neri… - … journal of molecular …, 2007 - spandidos-publications.com
Galanin is a regulatory 30-or 29-amino acid peptide, widely distributed in the nervous
system and gut, that acts via three subtypes of G protein-coupled receptors, named GAL-R1 …

Galanin and galanin receptors in human cancers

A Berger, R Santic, C Hauser-Kronberger, FH Schilling… - Neuropeptides, 2005 - Elsevier
The increasing interest in peptides and peptide receptors in cancer is based on the
possibility of receptor targeting, because peptide receptors are often expressed in different …

The galanin system in cancer

I Rauch, B Kofler - Galanin, 2010 - Springer
Many tumours of neuroendocrine origin, and also an increasing number of non-
neuroendocrine cancers, have been shown to express neuropeptides and/or their …