Reperfusion injury is a very common complication of various indicated therapies such as the
re-opening of vessels in the myocardium or brain as well as reflow in hemodynamic …

Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …

Background Numerous studies on myocardial ischemia/reperfusion (MI/R) injury have been
undertaken in recent years. Hotspots and developmental trends in MI/R research are being …

Abstract Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key
regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate …

Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac
contractility and hemodynamics are not known. Herein, we investigated (a) the effect of …

Background The metabolic and intracellular abnormalities in aging and diabetes cause loss
of cardioprotection by routine interventions against myocardial ischemia/reperfusion (I/R) …

Objective (s): Considering the poor prognosis of ischemic heart disease and the diminished
effectiveness of cardioprotective interventions in the elderly, it becomes necessary to …

Myocardial ischemia-reperfusion (I/R) injury stands out among cardiovascular diseases, and
current treatments are considered unsatisfactory. For cardiomyocytes (CMs) in ischemic …

The challenge of rapidly diagnosing myocardial ischemia in unstable angina (UA) patients
presenting to the Emergency Department (ED) is due to a lack of sensitive blood biomarkers …

Virtually all aspects of physiology fluctuate with respect to the time of day. This is beautifully
exemplified by cardiovascular physiology, for which blood pressure and electrophysiology …