From diagnosis to therapy in Duchenne muscular dystrophy
A Babbs, M Chatzopoulou, B Edwards… - Biochemical Society …, 2020 - portlandpress.com
Genetic approaches for the diagnosis and treatment of inherited muscle diseases have
advanced rapidly in recent years. Many of the advances have occurred in the treatment of …
advanced rapidly in recent years. Many of the advances have occurred in the treatment of …
Decreasing HepG2 cytotoxicity by lowering the lipophilicity of Benzo [d] oxazolephosphinate Ester Utrophin modulators
M Chatzopoulou, E Emer, C Lecci… - ACS Medicinal …, 2020 - ACS Publications
Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular
dystrophy that would be applicable to all patient populations. To improve the suboptimal …
dystrophy that would be applicable to all patient populations. To improve the suboptimal …
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid
M Chatzopoulou, TDW Claridge… - Journal of Medicinal …, 2019 - ACS Publications
5-(Ethylsulfonyl)-2-(naphthalen-2-yl) benzo [d] oxazole (ezutromid, 1) is a first-in-class
utrophin modulator that has been evaluated in a phase 2 clinical study for the treatment of …
utrophin modulator that has been evaluated in a phase 2 clinical study for the treatment of …