Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization

G Zhong - Trends in microbiology, 2021 - cell.com
Chlamydia trachomatis (CT) is frequently detected in the human gastrointestinal (GI) tract
despite its leading role in sexually transmitted bacterial infections in the genital tract …

Alterations of Vaginal Microbiota in Women With Infertility and Chlamydia trachomatis Infection

H Chen, L Wang, L Zhao, L Luo, S Min… - Frontiers in Cellular …, 2021 - frontiersin.org
Chlamydia trachomatis (C. trachomatis) is the most common etiological agent of bacterial
sexually transmitted infections (STIs) worldwide and causes serious health sequelae such …

The role of tryptophan in Chlamydia trachomatis persistence

L Wang, YL Hou, HX Yuan, H Chen - Frontiers in Cellular and …, 2022 - frontiersin.org
Chlamydia trachomatis (C. trachomatis) is the most common etiological agent of bacterial
sexually transmitted infections (STIs) and a worldwide public health issue. The natural …

IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut

Y He, Y Wang, R He, AM Abdelsalam… - Infection and …, 2023 - Am Soc Microbiol
An IFNγ-susceptible mutant of Chlamydia muridarum is attenuated in pathogenicity in the
genital tract and was recently licensed as an intr acellular O ral vaccine v ector or intrOv …

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

C Lu, J Wang, G Zhong - Infection and immunity, 2023 - Am Soc Microbiol
To search for subunit vaccine candidates, immunogenic chlamydial antigens identified in
humans were evaluated for protection against both infection and pathology in a mouse …

Genomic analysis of MSM rectal Chlamydia trachomatis isolates identifies predicted tissue-tropic lineages generated by intraspecies lateral gene transfer-mediated …

RJ Suchland, SJ Carrell, SA Ramsey… - Infection and …, 2022 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium that causes serious diseases in
humans. Rectal infection and disease caused by this pathogen are important yet …

Chlamydia deficient in plasmid-encoded glycoprotein 3 (pGP3) as an attenuated live oral vaccine

Z Zhou, Q Tian, L Wang, G Zhong - Infection and immunity, 2022 - Am Soc Microbiol
Despite the extensive efforts, there is still a lack of a licensed vaccine against Chlamydia
trachomatis in humans. The mouse genital tract infection with Chlamydia muridarum has …

Induction of transmucosal protection by oral vaccination with an attenuated Chlamydia

Y Wang, R He, H Winner, MC Gauduin… - Infection and …, 2023 - Am Soc Microbiol
Chlamydia muridarum has been used to study chlamydial pathogenesis because it induces
mice to develop hydrosalpinx, a pathology observed in C. trachomatis-infected women. We …

Regulation of chlamydial spreading from the small intestine to the large intestine by IL-22-producing CD4+ T cells

Y Xu, Y Wang, H Winner, H Yang, R He… - Infection and …, 2024 - Am Soc Microbiol
Following an oral inoculation, Chlamydia muridarum descends to the mouse large intestine
for long-lasting colonization. However, a mutant C. muridarum that lacks the plasmid …