[HTML][HTML] Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency
S Shen, ED Horowitz, AN Troupes, SM Brown… - Journal of Biological …, 2013 - ASBMB
Background: Viruses exploit cell surface glycans to infect host cells. Results: Different adeno-
associated viral serotypes were engineered to display functional galactose receptor …
associated viral serotypes were engineered to display functional galactose receptor …
[HTML][HTML] Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
N Meumann, M Cabanes‐Creus, M Ertelt… - Hepatology, 2023 - journals.lww.com
Conclusions: In conclusion, MLIV. K and MLIV. A are AAV peptide display variants selected
in immunocompetent mice with improved hepatocyte tropism and transduction efficiency …
in immunocompetent mice with improved hepatocyte tropism and transduction efficiency …
Structure of adeno-associated virus type 4
Adeno-associated virus (AAV) is a member of the Parvoviridae, belonging to the
Dependovirus genus. Currently, several distinct isolates of AAV are in development for use …
Dependovirus genus. Currently, several distinct isolates of AAV are in development for use …
[HTML][HTML] Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate
M Knappe, S Bodevin, HC Selinka, D Spillmann… - Journal of Biological …, 2007 - ASBMB
Efficient infection of cells by human papillomaviruses (HPVs) and pseudovirions requires
primary interaction with cell surface proteoglycans with apparent preference for species …
primary interaction with cell surface proteoglycans with apparent preference for species …
Structural insights into adeno-associated virus serotype 5
L Govindasamy, MA DiMattia, BL Gurda… - Journal of …, 2013 - Am Soc Microbiol
The adeno-associated viruses (AAVs) display differential cell binding, transduction, and
antigenic characteristics specified by their capsid viral protein (VP) composition. Toward …
antigenic characteristics specified by their capsid viral protein (VP) composition. Toward …
Human Bocavirus Capsid Structure: Insights into the Structural Repertoire of the Parvoviridae
BL Gurda, KN Parent, H Bladek, RS Sinkovits… - Journal of …, 2010 - Am Soc Microbiol
Human bocavirus (HBoV) was recently discovered and classified in the Bocavirus genus
(family Parvoviridae, subfamily Parvovirinae) on the basis of genomic similarity to bovine …
(family Parvoviridae, subfamily Parvovirinae) on the basis of genomic similarity to bovine …
Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking
The single-stranded DNA (ssDNA) parvoviruses enter host cells through receptor-mediated
endocytosis, and infection depends on processing in the early to late endosome as well as …
endocytosis, and infection depends on processing in the early to late endosome as well as …
[HTML][HTML] An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells
Gene delivery to, and gene targeting in, stem cells would be a highly enabling technology
for basic science and biomedical application. Adeno-associated viral (AAV) vectors have …
for basic science and biomedical application. Adeno-associated viral (AAV) vectors have …
[HTML][HTML] The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion
TF Lerch, Q Xie, MS Chapman - Virology, 2010 - Elsevier
Adeno-associated viruses (AAVs) are leading candidate vectors for human gene therapy.
AAV serotypes have broad cellular tropism and use a variety of cellular receptors. AAV …
AAV serotypes have broad cellular tropism and use a variety of cellular receptors. AAV …
Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism
L Perabo, D Goldnau, K White, J Endell… - Journal of …, 2006 - Am Soc Microbiol
Adeno-associated virus type 2 (AAV-2) targeting vectors have been generated by insertion
of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates …
of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates …