Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts

M Sen, G Ghosh - The Journal of Immunology, 2008 - journals.aai.org
Wnt-Frizzled signaling was first identified as a key event in Drosophila development. Over
the years, ample evidence has accumulated regarding the multiple roles of Wnt-Frizzled …

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts∗

N Case, M Ma, B Sen, Z Xie, TS Gross… - Journal of Biological …, 2008 - ASBMB
Mechanical loading of bone initiates an anabolic, anticatabolic pattern of response, yet the
molecular events involved in mechanical signal transduction are not well understood. Wnt/β …

Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node

B Sen, M Styner, Z Xie, N Case, CT Rubin… - Journal of Biological …, 2009 - ASBMB
Mechanical stimulation can prevent adipogenic and improve osteogenic lineage allocation
of mesenchymal stem cells (MSC), an effect associated with the preservation of β-catenin …

Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells

F Nunez, S Bravo, F Cruzat, M Montecino… - PloS one, 2011 - journals.plos.org
Background Increased expression of the cyclooxygenase-2 enzyme (COX2) is one of the
main characteristics of gastric cancer (GC), which is a leading cause of death in the world …

Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells

A Liedert, L Wagner, L Seefried, R Ebert… - Biochemical and …, 2010 - Elsevier
Bone mass homeostasis is regulated by an interaction of various factors, including growth
factors, systemic hormones and mechanical loading. Two signal transduction pathways, the …

LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes

J Elayyan, EJ Lee, O Gabay, CA Smith… - The FASEB …, 2017 - Wiley Online Library
Reduced SIRT1 activity and levels during osteoarthritis (OA) promote gradual loss of
cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase …

Mechanical loading activates β-catenin signaling in periodontal ligament cells

S Premaraj, I Souza, T Premaraj - The Angle Orthodontist, 2011 - meridian.allenpress.com
Objective: To determine whether β-catenin signaling is responsive to mechanical loading in
periodontal ligament (PDL) cells. Materials and Methods: To determine whether Wnt/β …

Lymphoid enhancer binding factor 1 regulates transcription through gene looping

K Yun, JS So, A Jash, SH Im - The Journal of Immunology, 2009 - journals.aai.org
Efficient transcription depends upon efficient physical and functional interactions between
transcriptosome complexes and DNA. We have previously shown that IL-1β-induced …

[HTML][HTML] Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes

S Ohba, TM Lanigan, BJ Roessler - Osteoarthritis and cartilage, 2010 - Elsevier
OBJECTIVE: Differentiated articular chondrocytes express a functional isoform of the leptin
receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We …

Looping mediated interaction between the promoter and 3′ UTR regulates type II collagen expression in chondrocytes

A Jash, K Yun, A Sahoo, JS So, SH Im - PLoS One, 2012 - journals.plos.org
Type II collagen is the major component of articular cartilage and is mainly synthesized by
chondrocytes. Repeated sub-culturing of primary chondrocytes leads to reduction of type II …