Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts
M Sen, G Ghosh - The Journal of Immunology, 2008 - journals.aai.org
Wnt-Frizzled signaling was first identified as a key event in Drosophila development. Over
the years, ample evidence has accumulated regarding the multiple roles of Wnt-Frizzled …
the years, ample evidence has accumulated regarding the multiple roles of Wnt-Frizzled …
β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts∗
N Case, M Ma, B Sen, Z Xie, TS Gross… - Journal of Biological …, 2008 - ASBMB
Mechanical loading of bone initiates an anabolic, anticatabolic pattern of response, yet the
molecular events involved in mechanical signal transduction are not well understood. Wnt/β …
molecular events involved in mechanical signal transduction are not well understood. Wnt/β …
Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node
Mechanical stimulation can prevent adipogenic and improve osteogenic lineage allocation
of mesenchymal stem cells (MSC), an effect associated with the preservation of β-catenin …
of mesenchymal stem cells (MSC), an effect associated with the preservation of β-catenin …
Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells
F Nunez, S Bravo, F Cruzat, M Montecino… - PloS one, 2011 - journals.plos.org
Background Increased expression of the cyclooxygenase-2 enzyme (COX2) is one of the
main characteristics of gastric cancer (GC), which is a leading cause of death in the world …
main characteristics of gastric cancer (GC), which is a leading cause of death in the world …
Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells
A Liedert, L Wagner, L Seefried, R Ebert… - Biochemical and …, 2010 - Elsevier
Bone mass homeostasis is regulated by an interaction of various factors, including growth
factors, systemic hormones and mechanical loading. Two signal transduction pathways, the …
factors, systemic hormones and mechanical loading. Two signal transduction pathways, the …
LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
Reduced SIRT1 activity and levels during osteoarthritis (OA) promote gradual loss of
cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase …
cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase …
Mechanical loading activates β-catenin signaling in periodontal ligament cells
S Premaraj, I Souza, T Premaraj - The Angle Orthodontist, 2011 - meridian.allenpress.com
Objective: To determine whether β-catenin signaling is responsive to mechanical loading in
periodontal ligament (PDL) cells. Materials and Methods: To determine whether Wnt/β …
periodontal ligament (PDL) cells. Materials and Methods: To determine whether Wnt/β …
Lymphoid enhancer binding factor 1 regulates transcription through gene looping
Efficient transcription depends upon efficient physical and functional interactions between
transcriptosome complexes and DNA. We have previously shown that IL-1β-induced …
transcriptosome complexes and DNA. We have previously shown that IL-1β-induced …
[HTML][HTML] Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes
S Ohba, TM Lanigan, BJ Roessler - Osteoarthritis and cartilage, 2010 - Elsevier
OBJECTIVE: Differentiated articular chondrocytes express a functional isoform of the leptin
receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We …
receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We …
Looping mediated interaction between the promoter and 3′ UTR regulates type II collagen expression in chondrocytes
Type II collagen is the major component of articular cartilage and is mainly synthesized by
chondrocytes. Repeated sub-culturing of primary chondrocytes leads to reduction of type II …
chondrocytes. Repeated sub-culturing of primary chondrocytes leads to reduction of type II …