This review provides a detailed discussion of recent advances in the medicinal chemistry of
camptothecin, a potent antitumor antibiotic. Two camptothecin analogues are presently …

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that
can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a …

Specific gene expression involves the binding of natural ligands to the DNA base pairs.
Among the compounds rationally designed for artificial regulation of gene expression …

Homocamptothecins (hCPTs) represent a new generation of antitumor agents targeting DNA
topoisomerase I. The expanded seven-membered lactone E-ring that characterizes hCPTs …

Oligonucleotides capable of sequence-specific triple helix formation have been proposed as
DNA binding ligands useful for modulation of gene expression and for directed genome …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

The ability to specifically manipulate gene expression has wide‐ranging applications in
experimental biology and in gene‐based therapeutics. The design of molecules that …

In this account we summarise recent studies on oligonucleotides and oligonucleotide
derivatives and their utilisation in antigene, antisense and decoy approaches, with particular …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Hairpin pyrrole− imidazole polyamides are synthetic ligands that bind in the minor groove of
DNA with affinities and specificities comparable to those of DNA binding proteins. Three …