apoB100 in the liver are constitutively synthesized, and that their secretion is regulated
mainly by the availability of the core lipids (triglycerides and cholesteryl esters) that they …

Rapid progress in human genome decoding has accelerated search for the role of gene
polymorphisms in the pathogenesis of complex multifactorial diseases. This review …

Conventional experimental methods of studying the human genome are limited by the
inability to independently study the combination of alleles, or haplotype, on each of the …

The recently identified apolipoprotein A5 gene (APOA5) has been shown to play an
important role in determining plasma triglyceride concentrations in humans and mice. We …

Since triglycerides (TG) are a major independent risk factor for coronary heart disease,
understanding their genetic and environmental determinants is of major importance. Mouse …

Apolipoprotein A5 (APOA5) is associated with differences in triglyceride levels and familial
combined hyperlipidemia. In genetically engineered mice, apoAV plasma levels are …

Alteration of single genes involved in nutrient and lipoprotein metabolism increases
longevity in several animal models. Because exceptional longevity in humans is familial, it is …

Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional or
genetic disturbances in homocysteine metabolism. A polymorphism in …

Peroxisome proliferator activated receptor (PPAR) alpha is a member of the nuclear receptor
superfamily that regulates key proteins involved in fatty acid oxidation, extracellular lipid …

Genetic variability at the APOA1/C3/A4/A5 cluster has been examined in relation to lipid
metabolism and cardiovascular disease risk. However, the findings are inconsistent. This is …