The voltage-gated sodium (NaV) channel NaV1. 7 has been identified as a potential novel
analgesic target due to its involvement in human pain syndromes. However, clinically …

Since the isolation of morphine from the opium poppy over 200 years ago, the molecular
basis of opioid action has remained the subject of intense inquiry. The identification of …

G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to
their pathophysiological significance and pharmacological relevance. Class A receptors …

Great progress has been made over the past decade in understanding the structural,
functional, and pharmacological diversity of lipid GPCRs. From the first determination of the …

The β 3-adrenergic receptor (β 3 AR) is predominantly expressed in adipose tissue and
urinary bladder and has emerged as an attractive drug target for the treatment of type 2 …

G protein-coupled receptors (GPCRs) are responsible for most cytoplasmic signaling in
response to extracellular ligands with different efficacy profiles. Various spectroscopic …

G protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology;
about one-third of all marketed drugs target members of this family. GPCR allosteric ligands …

A main rationale for the role of G protein-coupled receptor (GPCR) heteromers as targets for
drug development is the putative ability of selective ligands for specific GPCRs to change …

Highlights•Biased GPCR modulators provide various therapeutic benefits.•The number of
newly identified biased ligands is constantly increasing.•Understanding underlying receptor …

The design, synthesis, and discovery of dual-target compounds are considered as a
promising strategy to develop new drugs with improved safety and efficacy compared with …