Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and
modulates their affinity for bound ligands. However, the atomic-level basis for this allosteric …

An understanding of the kinetic contributions to G protein-coupled receptor pharmacology
and signaling is increasingly important in compound profiling. Nonequilibrium conditions are …

Signals from G-protein-coupled receptors (GPCRs) are the most frequently targeted
pathways of currently prescribed therapeutics. Rather than being a simple switch, it is now …

Cells are sensitive to chemical stimulation which is converted into intracellular biochemical
signals by the activation of specific receptors. Mechanical stimulations can also induce …

Agonists are defined as the ligands that activate intracellular signaling and evoke cellular
responses. Synthetic and endogenous agonists should bind specific amino acids to activate …

G protein coupled receptors (GPCRs) are a superfamily of transmembrane-spanning
receptors that are activated by multiple endogenous ligands and are the most common …

G-protein coupled receptors (GPCRs) control multiple physiological states by transducing a
multitude of extracellular stimuli into the cell via coupling to intra-cellular heterotrimeric G …

Abstract Background and Aim Standard pharmacological analysis of agonist activity utilises
measurements of receptor‐mediated responses at a set time‐point, or at the peak response …

Single-domain antibody fragments, also known as VHHs or nanobodies, have opened
promising avenues in therapeutics and in exploration of intracellular processes. Because of …

The insertase BamA is an essential protein of the bacterial outer membrane. Its 16-stranded
transmembrane β-barrel contains a lateral gate as a key functional element. This gate is …