The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …

Many flavonoids, as eminent phenolic compounds, have been commercialized and
consumed as dietary supplements due to their incredible human health benefits. In the …

The anti-cancer properties of plasma-treated solutions (PTS) and their interaction with drugs
are one of the most popular topics in modern plasma medicine. Our research involved …

Chemotherapy resistance is still a serious problem in the treatment of most cancers. Many
cellular and molecular mechanisms contribute to both inherent and acquired drug …

Gestagens are common pollutants accumulated in the aquatic ecosystem. Gestagens are
comprised of natural gestagens (ie progesterone) and synthetic gestagens (ie progestins) …

Background: Adrenocortical cancer (ACC) is a rare malignancy with a dismal prognosis. The
treatment includes mitotane and EDP chemotherapy (etoposide, doxorubicin, and cisplatin) …

Immune checkpoint inhibitors highlight the importance of anticancer immunity. However,
their clinical utility and safety are limited by the low response rates and adverse effects. We …

Actual mechanisms of multidrug resistance (MDR) to chemotherapy in oncology are
considered. ABC-transporters such as P-glycoprotein, BCRP protein, and MRP proteins take …

Abstract Cyclin-dependent kinase 6 (CDK6) participates in numerous signalling pathways
and regulates various physiological processes. Due to its unique structural features and …

The permeability transition pore in mitochondria (MPTP) and the ATP-binding cassette
transporters (АВС transporters) in cell membranes provide the efflux of low-molecular …