The roles of histone deacetylases and their inhibitors in cancer therapy

G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily

J Song, Y He, C Luo, B Feng, F Ran, H Xu, Z Ci… - Pharmacological …, 2020 - Elsevier
Protocatechuic acid is a natural phenolic acid, which widely exists in our daily diet and
herbs. It is also one of the main metabolites of complex polyphenols, such as anthocyanins …

Overview of the antioxidant and anti-inflammatory activities of selected plant compounds and their metal ions complexes

P Mucha, A Skoczyńska, M Małecka, P Hikisz… - Molecules, 2021 - mdpi.com
Numerous plant compounds and their metal-ion complexes exert antioxidative, anti-
inflammatory, anticancer, and other beneficial effects. This review highlights the different …

Oxidative stress, inflammation and hormesis: The role of dietary and lifestyle modifications on aging

V Sharma, MM Mehdi - Neurochemistry international, 2023 - Elsevier
Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

Natural antioxidant evaluation: A review of detection methods

JS Mendonça, RCA Guimarães, VA Zorgetto-Pinheiro… - Molecules, 2022 - mdpi.com
Antioxidants have drawn the attention of the scientific community due to being related to the
prevention of various degenerative diseases. The antioxidant capacity has been extensively …

Total antioxidant capacity: biochemical aspects and clinical significance

A Silvestrini, E Meucci, BM Ricerca… - International Journal of …, 2023 - mdpi.com
Despite the physiological role of oxidant molecules, oxidative stress (OS) could underlie
several human diseases. When the levels of antioxidants are too low or too high, OS occurs …

[HTML][HTML] Interplay between gut microbiota and antimicrobial peptides

X Zong, J Fu, B Xu, Y Wang, M Jin - Animal Nutrition, 2020 - Elsevier
The gut microbiota is comprised of a diverse array of microorganisms that interact with
immune system and exert crucial roles for the health. Changes in the gut microbiota …

Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation

T Hou, Y Tian, Z Cao, J Zhang, T Feng, W Tao, H Sun… - Molecular Cell, 2022 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid
accumulation, which can progress to nonalcoholic steatohepatitis (NASH). Histone …

Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress

L Zhao, M Liu, H Sun, JC Yang, YX Huang… - Science China Life …, 2023 - Springer
Broiler chicks are fast-growing and susceptible to dietary selenium (Se) deficiency. This
study sought to reveal the underlying mechanisms of how Se deficiency induces key organ …

Recent overview of potent antioxidant activity of coordination compounds

HMA El-Lateef, T El-Dabea, MM Khalaf, AM Abu-Dief - Antioxidants, 2023 - mdpi.com
During recent decades, the complexation of organic ligands toward several metal ions of sp
and d-block has been applied as a plan to enhance its antioxidant performance. Due to their …