[HTML][HTML] Non-viral vectors in gene therapy: recent development, challenges, and prospects

H Zu, D Gao - The AAPS journal, 2021 - Springer
Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …

[HTML][HTML] Progress in mesoporous silica nanoparticles as drug delivery agents for cancer treatment

ED Mohamed Isa, H Ahmad, MB Abdul Rahman… - Pharmaceutics, 2021 - mdpi.com
Cancer treatment and therapy have made significant leaps and bounds in these past
decades. However, there are still cases where surgical removal is impossible, metastases …

[HTML][HTML] Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

B Siddiqui, I Haq, AA Al-Dossary, A Elaissari… - International Journal of …, 2022 - Elsevier
Rapid progress in developing multifunctional nanocarriers for drug delivery has been
observed in recent years. Inorganic mesoporous silica nanocarriers (MSNs), emerged as an …

Mesoporous silica nanoparticles: Synthesis and multifaceted functionalization for controlled drug delivery

J Gupta, M Quadros, M Momin - Journal of Drug Delivery Science and …, 2023 - Elsevier
Inorganic mesoporous silica nanoparticles (MSN) are porous materials extensively studied
for drug delivery due to their properties such as facile and diverse synthesis methods …

Engineered mesoporous silica nanoparticles, new insight nanoplatforms into effective cancer gene therapy

R Heidari, V Assadollahi, P Khosravian… - International Journal of …, 2023 - Elsevier
The use of nucleic acid to control the expression of genes relevant to tumor progression is a
key therapeutic approach in cancer research. Therapeutics based on nucleic acid provide …

Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications

J Yang, KM Luly, JJ Green - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers

Y Wang, K Gou, X Guo, J Ke, S Li, H Li - Acta Biomaterialia, 2021 - Elsevier
Mesoporous silica nanoparticles (MSNs) with remarkable structural features have been
proven to be an excellent platform for the delivery of therapeutic molecules. Biological …

[HTML][HTML] Delivery of natural agents by means of mesoporous silica nanospheres as a promising anticancer strategy

K AbouAitah, W Lojkowski - Pharmaceutics, 2021 - mdpi.com
Natural prodrugs derived from different natural origins (eg, medicinal plants, microbes,
animals) have a long history in traditional medicine. They exhibit a broad range of …

[HTML][HTML] Recent advances in mesoporous silica nanoparticle-mediated drug delivery for breast cancer treatment

R Rani, P Malik, S Dhania, TK Mukherjee - Pharmaceutics, 2023 - mdpi.com
Breast cancer (BC) currently occupies the second rank in cancer-related global female
deaths. Although consistent awareness and improved diagnosis have reduced mortality in …

Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment

T Hailing, P Yonghong, Z Yufeng, T Haitao - Journal of Controlled Release, 2022 - Elsevier
Abnormal regulation of cell signaling pathways on cell survival, proliferation and migration
contributes to the development of malignant tumors. Among them, epidermal growth factor …