Research progress on the synthesis and pharmacology of 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole derivatives: a mini review

JJ Wang, W Sun, WD Jia, M Bian… - Journal of Enzyme …, 2022 - Taylor & Francis
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …

[HTML][HTML] Benzimidazole and its derivatives: Recent Advances (2020–2022)

O Ebenezer, F Oyetunde-Joshua, OD Omotoso… - Results in …, 2023 - Elsevier
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …

Synthesis, single crystal, TD-DFT, molecular dynamics simulation and DNA binding studies of carbothioamide analog

M Rana, S Ahmedi, A Fatima, S Ahmad… - Journal of Molecular …, 2023 - Elsevier
In this work, analog 3b (5-(4-(dimethylamino) phenyl)-3-(4-methoxyphenyl)-4, 5-dihydro-1H-
pyrazole-1-carbothioamide) of pyrazoline derivative was produced based on the active site …

Synthesis of benzimidazole-1, 2, 4-triazole derivatives as potential antifungal agents targeting 14α-demethylase

E Guzel, U Acar Çevik, AE Evren, HE Bostancı… - ACS …, 2023 - ACS Publications
Invasive fungal infections (IFIs) are increasing as major infectious diseases around the
world, and the limited efficacy of existing medications has resulted in substantial morbidity …

Anti-quorum sensing, antibiofilm, and antibacterial activities of extracts of Centella asiatica L. leaves, and in vitro derived leaves-calli through tissue culture: a …

MA Khan, HM Khan, IB Ganie, S Kumar, A Shahzad… - Biofouling, 2022 - Taylor & Francis
Extracts of Centella asiatica leaves (LEs), and in-vitro leaf-calli (CEs), were investigated for
antibacterial, antibiofilm, and anti-quorum sensing activities. Ethyl acetate extracts from …

Recent advances in the anticancer applications of benzimidazole derivatives

M Mavvaji, S Akkoc - ChemistrySelect, 2023 - Wiley Online Library
Cancer, one of the most deadly diseases worldwide, is still a crucial challenge to human
well‐being. Hence, the design and development of modern protocols to cure diverse kinds …

Exploration of Remarkably Potential Multitarget-Directed N-Alkylated-2-(substituted phenyl)-1H-benzimidazole Derivatives as Antiproliferative, Antifungal, and …

NKN Phan, TKC Huynh, HP Nguyen, QT Le… - ACS …, 2023 - ACS Publications
Improving lipophilicity for drugs to penetrate the lipid membrane and decreasing bacterial
and fungal coinfections for patients with cancer pose challenges in the drug development …

[HTML][HTML] The depsidones from marine sponge-derived fungus Aspergillus unguis IB151 as an anti-MRSA agent: Molecular docking, pharmacokinetics analysis, and …

D Handayani, I Aminah, PP Putra, AE Putra… - Saudi Pharmaceutical …, 2023 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging nosocomial pathogen
among hospitalized patients, with high morbidity and mortality rates. The discovery of a …

Recent advances in the application of heterogeneous catalysts for the synthesis of benzimidazole derivatives

M Mavvaji, S Akkoc - Coordination Chemistry Reviews, 2024 - Elsevier
Benzimidazole derivatives have exhibited marvelous utility due to their widespread
pharmaceutical features, including anti-fungal, anti-viral, anti-bacterial, anti-cancer, anti …

Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole–Thiadiazole Hybrids

I Celik, UA Çevik, A Karayel, A Işık, U Kayış… - ACS …, 2022 - ACS Publications
In this study, some new compounds, which are 2-aminothiadiazole derivatives linked by a
phenyl bridge to the 2-position of the benzimidazole ring, were designed and synthesized as …