High-grade gliomas in children are different from those that arise in adults. Recent
collaborative molecular analyses of these rare cancers have revealed previously …

Since the update of the 4th edition of the WHO Classification of Central Nervous System
(CNS) Tumors published in 2016, particular molecular characteristics are part of the …

Ependymal tumors across age groups are currently classified and graded solely by
histopathology. It is, however, commonly accepted that this classification scheme has limited …

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-
specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot …

Radiologists play a key role in brain tumor diagnosis and management and must stay
abreast of developments in the field to advance patient care and communicate with other …

For nearly a century, the diagnosis and grading of oligodendrogliomas and
oligoastrocytomas has been based on histopathology alone. Roughly 20 years ago, the first …

Brain tumors are the leading cause of cancer-related death in children. Genomic studies
have provided insights into molecular subgroups and oncogenic drivers of pediatric brain …

The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …

Central nervous system (CNS) tumors are the most common solid tumor in pediatrics,
accounting for approximately 25% of all childhood cancers, and the second most common …

Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …