Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

In chronic obstructive pulmonary disease (COPD), exacerbations are generally associated
with several causes, including pollutants, viruses, bacteria that are responsible for an excess …

Pilewski, Joseph M., and Raymond A. Frizzell. Role of CFTR in Airway Disease. Physiol.
Rev. 79, Suppl.: S215–S255, 1999.—Cystic fibrosis (CF) is caused by mutations in the gene …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

Previous studies in native tissues have produced conflicting data on the localization and
metabolic fate of WT and ΔF508 cystic fibrosis transmembrane regulator (CFTR) in the lung …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) protein, an epithelial chloride channel expressed in the airways, pancreas, testis …

Serous cells are the predominant site of cystic fibrosis transmembrane conductance
regulator expression in the airways, and they make a significant contribution to the volume …

Human airway mucins represent a very broad family of polydisperse high molecular mass
glycoproteins, which are part of the airway innate immunity. Apomucins, which correspond to …

Fluid and macromolecule secretion by submucosal glands in mammalian airways is
believed to be important in normal airway physiology and in the pathophysiology of cystic …