Abstract Background The cJun-N-terminal-kinase (JNK) plays a central role in the cell stress
response, with outcomes ranging from cell death to cell proliferation and survival, depending …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

Stem cell implantation strategy has exhibited potential to treat the myocardial infarction (MI),
however, the low retention and survival limit their applications due to the reactive oxygen …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

With the development of nanotechnology and the wide use of graphene, it has become
necessary to assess the potential biological adverse effects of graphene. However, most of …

Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase
cascades in their repertoire of signal transduction mechanisms. Recent advances in the …

The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in
mammals and insects. JNK is activated by exposure of cells to cytokines or environmental …

Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that
are activated by dual phosphorylation on threonine and tyrosine residues in response to a …

Multiple signal transduction pathways are capable of modifying BCL-2 family members to
reset susceptibility to apoptosis. We used two-dimensional peptide mapping and …