The two MAP kinases JNK and ERK direct distinct cellular activities even though they share
a number of common substrates, including several transcription factors. Here we have …

Mechanical stresses are important environmental cues for both normal cellular functions and
pathophysiological changes in conditions such as cardiac hypertrophy and atherosclerosis …

Certain cell types undergo apoptosis when they lose integrin-mediated contacts with the
extracellular matrix (" anoikis"). The Jun N-terminal kinase (JNK) pathway is activated in and …

Cadmium (Cd), a human carcinogen, can induce apoptosis in various cell types. Three
major mitogen-activated protein kinases (MAPKs), c-JUN N-terminal kinase (JNK), p38 and …

The response of cells to extracellular stimuli is mediated in part by a number of intracellular
kinase and phosphatase enzymes. Within this area of research the activation of the p42 and …

▪ Abstract Since the discovery that cells can activate their own suicide program, investigators
have attempted to determine whether the events that are associated with this form of cell …

Mitogen-activated protein kinases (MAPKs) are critical components of a complex
intracellular signalling network that ultimately regulates gene expression in response to a …

Fas ligand and tumor necrosis factor α (TNF) bind to members of the TNF receptor
superfamily. Stimulation by Fas ligand results in apoptosis, whereas TNF induces multiple …

Regulation of the mitogen-activated protein kinase (MAPK) family members—which include
the extracellular response kinases (ERKs), p38/HOG1, and the c-Jun amino-terminal …

Anti-apoptotic effect of quercetin: Intervention in the JNK-and ERK-mediated apoptotic
pathways. Background Bioflavonoid quercetin inhibits hydrogen peroxide (H 2 O 2)-induced …