The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

Enabling the examination of cell-cell relationships in tissue, spatially resolved omics
technologies have revolutionised our perspectives on cancer biology. Clinically, the …

Small-cell lung cancer (SCLC) is generally considered a'homogenous' disease, with little
documented inter-tumor heterogeneity in treatment guidance or prognosis evaluation. The …

Background KN046 is a novel bispecific antibody targeting programmed death ligand 1 (PD-
L1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4). This multicenter phase I trial …

Immunotherapies have revolutionized cancer treatment approaches. Because not all
patients respond positively to immune therapeutic agents, it represents a challenge for …

Background Patients who possess various histological subtypes of early‐stage lung
adenocarcinoma (LUAD) have considerably diverse prognoses. The simultaneous …

Objective Early-stage lung adenocarcinoma is treated with local therapy alone, although
patients with grade 3 stage I lung adenocarcinoma have a 50% 5-year recurrence rate. Our …

Simple Summary The incidence of biliary tract cancers (BTCs) is rising. Although therapeutic
weapons are still limited, a better knowledge of the molecular landscape of these tumors has …

Malignant tumors have increasing morbidity and high mortality, and their occurrence and
development is a complicate process. The development of sequencing technologies …

Angiogenesis, metastasis, and resistance to therapy are all facilitated by cancer-associated
fibroblasts (CAFs). A CAF-based risk signature can be used to predict patients' prognoses …