[HTML][HTML] Repurposing cholinesterase inhibitors as antidepressants? Dose and stress-sensitivity may be critical to opening possibilities
When stress becomes chronic it can trigger lasting brain and behavioral changes including
Major Depressive Disorder (MDD). There is conflicting evidence regarding whether …
Major Depressive Disorder (MDD). There is conflicting evidence regarding whether …
Cortical VIP+/ChAT+ interneurons: From genetics to function
One of the urgent tasks of neuroscience is to understand how neuronal circuits operate,
what makes them fail, and how to repair them when needed. Achieving this goal requires …
what makes them fail, and how to repair them when needed. Achieving this goal requires …
[HTML][HTML] The anti-inflammatory effect of the tricyclic antidepressant clomipramine and its high penetration in the brain might be useful to prevent the psychiatric …
B Nobile, M Durand, S Guillaume, JP Molès… - Frontiers in …, 2021 - frontiersin.org
At the time of writing (December 2020), coronavirus disease 2019 (COVID-19) has already
caused more than one million deaths worldwide, and therefore, it is imperative to find …
caused more than one million deaths worldwide, and therefore, it is imperative to find …
[HTML][HTML] Dose-dependent dissociation of pro-cognitive effects of donepezil on attention and cognitive flexibility in rhesus monkeys
Background Donepezil exerts pro-cognitive effects by nonselectively enhancing
acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro …
acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro …
[PDF][PDF] Chrna5 and lynx prototoxins identify acetylcholine super-responder subplate neurons
Attention depends on cholinergic excitation of prefrontal neurons but is sensitive to
perturbation of α5-containing nicotinic receptors encoded by Chrna5. However, Chrna5 …
perturbation of α5-containing nicotinic receptors encoded by Chrna5. However, Chrna5 …
[HTML][HTML] CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease
J Rybnicek, Y Chen, M Milic, ES Tio… - Translational …, 2024 - nature.com
Abstract Changes in high-affinity nicotinic acetylcholine receptors are intricately connected
to neuropathology in Alzheimer's Disease (AD). Protective and cognitive-enhancing roles for …
to neuropathology in Alzheimer's Disease (AD). Protective and cognitive-enhancing roles for …
[HTML][HTML] Age impacts the burden that reference memory imparts on an increasing working memory load and modifies relationships with cholinergic activity
VE Bernaud, R Hiroi, ML Poisson… - Frontiers in Behavioral …, 2021 - frontiersin.org
Rodent aging research often utilizes spatial mazes, such as the water radial-arm-maze
(WRAM), to evaluate cognition. The WRAM can simultaneously measure spatial working …
(WRAM), to evaluate cognition. The WRAM can simultaneously measure spatial working …
Chrna5 is essential for a rapid and protected response to optogenetic release of endogenous acetylcholine in prefrontal cortex
S Venkatesan, EK Lambe - Journal of Neuroscience, 2020 - Soc Neuroscience
Optimal attention performance requires cholinergic modulation of corticothalamic neurons in
the prefrontal cortex. These pyramidal cells express specialized nicotinic acetylcholine …
the prefrontal cortex. These pyramidal cells express specialized nicotinic acetylcholine …
[HTML][HTML] Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071
A Kucinski, M Sarter - Psychopharmacology, 2021 - Springer
Rationale In addition to the disease-defining motor symptoms, patients with Parkinson's
disease (PD) exhibit gait dysfunction, postural instability, and a propensity for falls. These …
disease (PD) exhibit gait dysfunction, postural instability, and a propensity for falls. These …
Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models
SK Power, S Venkatesan, S Qu, JA McLaurin… - bioRxiv, 2023 - biorxiv.org
Background: Cognitive reserve allows for active compensation during neuropathology.
Here, we examine electrophysiological evidence for active compensation in Alzheimer's …
Here, we examine electrophysiological evidence for active compensation in Alzheimer's …