The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA
methylation, histone modifications, chromatin remodeling, and non-coding RNA species …

Embryonic stem cells (ESCs) and induced pluripotent stem cells have the potential to
differentiate to all cell types of an adult individual and are useful for studying development …

Understanding preimplantation embryonic development is crucial for the improvement of
assisted reproductive technologies and animal production. To achieve this goal, it is …

Aberrant epigenetic reprogramming is a major factor of developmental failure of cloned
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …

DNA methylation is an important epigenetic modification that undergoes dynamic changes
in mammalian embryogenesis, during which both parental genomes are reprogrammed …

In somatic cell nuclear transfer (SCNT) embryos, developmental defects first appear at the
time of zygotic genome activation (ZGA), a process that is under the control of DNA and …

Background Sperm epigenetics is an emerging area of study supported by observations
reporting that abnormal sperm DNA methylation patterns are associated with infertility. Here …

Embryo culture conditions are crucial as they can affect embryo quality and even offspring.
Oviductal extracellular vesicles (EVs) long been considered a major factor influencing …

In many cell types, epigenetic changes are partially regulated by the availability of
metabolites involved in the activity of chromatin-modifying enzymes. Even so, the …

Animal cloning has been achieved in many species by transplanting differentiated cell
nuclei to unfertilized oocytes. However, the low efficiencies of cloning have remained an …