Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Introduction Light microscopy examination of blood slides is the main method of detecting
malaria infection; however, it has limited sensitivity. Low-density infections are most likely to …

Hitting Hotspots: Spatial Targeting of Malaria for Control and Elimination | PLOS Medicine Skip
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Malaria infections occurring below the limit of detection of standard diagnostics are common
in all endemic settings. However, key questions remain surrounding their contribution to …

Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after
repeated exposure. Knowledge of the acquisition and nature of protective immune …

Background The efficacy of anti-malarial drugs is assessed over a period of 28-63 days
(depending on the drugs' residence time) following initiation of treatment in order to capture …

Background Natural immunity to Plasmodium falciparum has been widely studied, but its
effects on parasite dynamics are poorly understood. Acquisition and clearance rates of …

Background Amplicon deep sequencing permits sensitive detection of minority clones and
improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections …

After more than 50 years of intensive research and development, only one malaria vaccine
candidate,“RTS, S,” has progressed to Phase 3 clinical trials. Despite only partial efficacy …

Introduction Solomon Islands is intensifying national efforts to achieve malaria elimination. A
long history of indoor spraying with residual insecticides, combined recently with distribution …