Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac
function in clinical and experimental research. Significant progress in the development of …

Background: Metabolic remodeling in heart failure contributes to dysfunctional lipid
trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty …

Heart disease is the leading cause of hospitalization and death worldwide, severely
affecting health care costs. Aging is a significant risk factor for heart disease, and the …

Acute or chronic myocardial infarction (MI) are cardiovascular events resulting in high
morbidity and mortality. Establishing the pathological mechanisms at work during MI and …

Thiazolidinediones are useful antidiabetic medications. However, their use is associated
with adverse side effects like edema, heart failure and bone fractures. In this study, we …

The anti-aging protein Klotho has been associated with cardiovascular health protection.
Nevertheless, the protective mechanism remains unknown. The present study is aimed at …

We previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-
inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we …

Background: Myocardial insulin resistance is a hallmark of diabetic cardiac injury. However,
the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the …

ERβ (oestrogen receptor β) activation has been shown to be cardioprotective, but the cell
types and mechanisms involved are not understood. To investigate whether ERβ restricted …