[HTML][HTML] Emerging roles of SIRT1 in fatty liver diseases
Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …
consumption and/or other metabolic disorder causes, lead to serious medical concerns …
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
C Tatone, G Di Emidio, A Barbonetti… - Human …, 2018 - academic.oup.com
Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …
that catalyze post-translational modifications of proteins. Together, they respond to …
Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production
Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …
Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications
NAD+ is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD+ can be severely perturbed. On one …
complications, the balance between NADH and NAD+ can be severely perturbed. On one …
Sirt1: role under the condition of ischemia/hypoxia
X Meng, J Tan, M Li, S Song, Y Miao… - Cellular and Molecular …, 2017 - Springer
Silent information regulator factor 2-related enzyme 1 (sirtuin 1, Sirt1) is a nicotinamide
adenine dinucleotide-dependent deacetylase, which can deacetylate histone and non …
adenine dinucleotide-dependent deacetylase, which can deacetylate histone and non …
[HTML][HTML] Hyperglycemic stress and carbon stress in diabetic glucotoxicity
X Luo, J Wu, S Jing, LJ Yan - Aging and disease, 2016 - ncbi.nlm.nih.gov
Diabetes and its complications are caused by chronic glucotoxicity driven by persistent
hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by …
hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by …
The pathobiology of polycystic kidney disease from a metabolic viewpoint
LF Menezes, GG Germino - Nature Reviews Nephrology, 2019 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 1 in 1,000
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …
SGLT2 inhibitors as calorie restriction mimetics: insights on longevity pathways and age-related diseases
CWS Hoong, MWJ Chua - Endocrinology, 2021 - academic.oup.com
Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors induce glycosuria, reduce
insulin levels, and promote fatty acid oxidation and ketogenesis. By promoting a nutrient …
insulin levels, and promote fatty acid oxidation and ketogenesis. By promoting a nutrient …
Role of NRF2 and Sirtuin activators in COVID-19
H Khan, S Patel, A Majumdar - Clinical Immunology, 2021 - Elsevier
COVID-19 is a pandemic requiring immediate solution for treatment because of its complex
pathophysiology. Exploration of novel targets and thus treatment will be life savers which is …
pathophysiology. Exploration of novel targets and thus treatment will be life savers which is …
Metabolic syndrome and cardiac remodeling due to mitochondrial oxidative stress involving gliflozins and sirtuins
RL Sanz, F Inserra, S Garcia Menendez… - Current Hypertension …, 2023 - Springer
Abstract Purpose of Review To address the mechanistic pathways focusing on mitochondria
dysfunction, oxidative stress, sirtuins imbalance, and other contributors in patient with …
dysfunction, oxidative stress, sirtuins imbalance, and other contributors in patient with …