Rationale Muscle atrophy confers a poor prognosis in patients with chronic obstructive
pulmonary disease (COPD), yet the molecular pathways responsible are poorly …

MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes
by modulating gene expression at the post-transcriptional level. It has become increasingly …

Systematic physical activity increases physical fitness and exercise capacity that lead to the
improvement of health status and athletic performance. Considerable effort is devoted to …

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding
dystrophin, which results in dysfunctional signaling pathways within muscle. Previously, we …

In patients with Duchenne muscular dystrophy (DMD), the absence of a functional
dystrophin protein results in sarcolemmal instability, abnormal calcium signaling …

Skeletal muscle possesses a strong ability to regenerate following injury, a fact that has
been largely attributed to satellite cells. Satellite cells are skeletal muscle stem cells located …

Muscle development, growth, and maintenance require an intricate and timely series of
events initiated through a multitude of signaling pathways. The very nature of skeletal …

MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this
study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are …

Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an
increased risk of falls and fractures among the elderly. Aged mice and elderly adults both …

Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To date, there is no effective therapeutic approach …