OBJECTIVE Factors governing microRNA expressions in response to changes of cellular
environment are still largely unknown. Our aim was to determine whether insulin, the major …

MicroRNAs (miRNAs) are short non-coding RNAs, highly conserved between species, that
are powerful regulators of gene expression. Aberrant expression of miRNAs alters biological …

Introduction: Obesity and obesity-related disease have reached pandemic proportions and
are prevalent even in developing countries. Adipose tissue is increasingly being recognized …

Dermatomyositis (DM), antisynthetase syndrome (AS), immune-mediated necrotizing
myopathy (IMNM), and inclusion body myositis (IBM) are four major types of idiopathic …

Duchenne muscular dystrophy (DMD)—which is caused by mutations in the dystrophin gene—
is one of the most severe myopathies. Among therapeutic strategies, exon skipping allows …

Skeletal muscle degenerates progressively, losing mass (sarcopenia) over time, which
leads to reduced physical ability and often results in secondary diseases such as diabetes …

A healthy and independent life requires skeletal muscles to maintain optimal function
throughout the lifespan, which is in turn dependent on efficient activation of processes that …

Myotonic Dystrophy Type-1 (DM1) is caused by the expansion of a CTG repeat with a
peculiar pattern of multisystemic involvement affecting skeletal muscles, the heart, the eye …

Skeletal muscle makes up approximately 40% of the total body mass, providing structural
support and enabling the body to maintain posture, to control motor movements and to store …

Essential amino acids (EAA) stimulate muscle protein synthesis in humans. However, little is
known about whether microRNAs (miRNA) and genes associated with muscle growth are …