Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

The gut microbial community (Gut microbiota) is known to impact metabolic functions as well
as immune responses in our body. Diet plays an important role in determining the …

How antigen valency affects B cells in vivo during immune responses is not well understood.
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …

Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

Cancer immunotherapy attempts to harness the power and specificity of the immune system
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …

Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …

In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes,
into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal …

Inflammation plays an essential role in the control of pathogens and in shaping the ensuing
adaptive immune responses. Traditionally, innate immunity has been described as a rapid …

As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous
cell population with significant cellular phenotypic and functional plasticity. They form a …

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of
pathological processes including tissue inflammation and tumor dissemination but is …