Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …

Diabetic kidney disease (DKD) remains a leading cause of new-onset end-stage renal
disease (ESRD), and yet, at present, the treatment is still very limited. A better understanding …

Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B
can explain the majority of cases of primary membranous nephropathy (MN). However …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins that
constitutes the scaffold of multicellular organisms. In addition to providing architectural and …

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease in the United
States and is a major cause of cardiovascular disease and death. DN develops insidiously …

Podocytes are specialized epithelial cells that cover the outer surfaces of glomerular
capillaries. Unique cell junctions, known as slit diaphragms, which feature nephrin and …