Historically, epidemiological investigation and surveillance for bacterial antimicrobial
resistance (AMR) has relied on low-resolution isolate-based phenotypic analyses …

Antimicrobial resistance (AMR) is a major global public health threat, which has been largely
driven by the excessive use of antimicrobials. Control measures are urgently needed to slow …

Infections caused by metallo-beta-lactamase-producing organisms (MBLs) are a global
health threat. Our understanding of transmission dynamics and how MBLs establish …

The rapid spread of carbapenemase-producing Klebsiella pneumoniae (cpKP) poses
serious threats to public health; however, the underlying genetic basis for its dissemination …

Plasmids are a major driver of horizontal gene transfer in prokaryotes, allowing the sharing
of ecologically important accessory traits between distantly related bacterial taxa. Within …

Abstract Background Carbapenem-resistant Enterobacterales (CRE) are an urgent global
health threat. Inferring the dynamics of local CRE dissemination is currently limited by our …

Introduction Klebsiella pneumoniae is a major agent of healthcare-associated infections and
a cause of some community-acquired infections, including severe bacteremic infections …

Antimicrobial resistance (AMR) is a global threat, with evolution and spread of resistance to
frontline antibiotics outpacing the development of novel treatments. The spread of AMR is …

The emergence of carbapenem resistance is a major public health threat in sub-Saharan
Africa but remains poorly understood, particularly at the human-animal-environment …

Carbapenem-resistant Enterobacterales (CRE) pose a significant threat to global public
health. The most important mechanism for carbapenem resistance is the production of …