Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …

Spinal cord injury (SCI) results in a wide range of disabilities. Its complex pathophysiological
process limits the effectiveness of many clinical treatments. Betulinic acid (BA) has been …

Pyroptosis is a form of programmed cell death activated by various stimuli and is
characterized by inflammasome assembly, membrane pore formation, and the secretion of …

Pyroptosis has garnered increasing attention in cancer immunotherapy. Moreover,
increasing plasma membrane damage by reactive oxygen species (ROS) is considered an …

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Millions of patients are suffering from ischemic stroke, it is urgent to figure out the
pathogenesis of cerebral ischemia–reperfusion (I/R) injury in order to find an effective cure …

Lysosomal cysteine cathepsins are a family of proteases that are involved in a myriad of
cellular processes from proteolytic degradation in the lysosome to bone resorption. These …

The majority of current cancer immunotherapy strategies target and potentiate antitumor
adaptive immune responses. Unfortunately, the efficacy of these treatments has been limited …

Gout is an autoinflammatory disease caused by the deposition of urate crystals. As the most
common inflammatory arthritis, gout has a high incidence and can induce various severe …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …