Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …

Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disorder
of the small intestine and colon. IBD includes ulcerative colitis (UC) and Crohn's disease …

Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-
induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA) …

The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of
NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative …

Although immune checkpoint blockers have yielded significant clinical benefits in patients
with different malignancies, the efficacy of these therapies is still limited. Here, we show that …

The mortality of sepsis-induced cardiac dysfunction (SICD) is very high due to the complex
pathophysiological mechanism. Syringaresinol (SYR) is a natural abstract which possesses …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin protein-mediated membrane pore formation, cell swelling, and rapid lysis …

Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …

Background The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-
dependent pyroptosis has been shown to play a vital role in the pathology of manganese …

Crystal structures activate innate immune cells, especially macrophages and initiate
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …