Anomalous transport in the crowded world of biological cells

F Höfling, T Franosch - Reports on Progress in Physics, 2013 - iopscience.iop.org
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …

Heterogeneous anomalous transport in cellular and molecular biology

TA Waigh, N Korabel - Reports on Progress in Physics, 2023 - iopscience.iop.org
It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

Multifunctional mesoporous silica nanoparticles as a universal platform for drug delivery

C Argyo, V Weiss, C Bräuchle, T Bein - Chemistry of materials, 2014 - ACS Publications
Nanosized mesoporous silica particles with high colloidal stability attract growing attention
as drug delivery systems for targeted cancer treatment and as bioimaging devices. This …

Intracellular transport of insulin granules is a subordinated random walk

SMA Tabei, S Burov, HY Kim… - Proceedings of the …, 2013 - National Acad Sciences
We quantitatively analyzed particle tracking data on insulin granules expressing fluorescent
fusion proteins in MIN6 cells to better understand the motions contributing to intracellular …

Elucidating the origin of heterogeneous anomalous diffusion in the cytoplasm of mammalian cells

A Sabri, X Xu, D Krapf, M Weiss - Physical Review Letters, 2020 - APS
Diffusion of tracer particles in the cytoplasm of mammalian cells is often anomalous with a
marked heterogeneity even within individual particle trajectories. Despite considerable …

Anomalous diffusion and ergodicity breaking in heterogeneous diffusion processes

AG Cherstvy, AV Chechkin, R Metzler - New Journal of Physics, 2013 - iopscience.iop.org
We demonstrate the non-ergodicity of a simple Markovian stochastic process with space-
dependent diffusion coefficient D (x). For power-law forms D (x)≃| x| α, this process yields …

[HTML][HTML] Getting around the cell: physical transport in the intracellular world

SS Mogre, AI Brown, EF Koslover - Physical Biology, 2020 - iopscience.iop.org
Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Comparative analysis of viscosity of complex liquids and cytoplasm of mammalian cells at the nanoscale

T Kalwarczyk, N Ziebacz, A Bielejewska… - Nano …, 2011 - ACS Publications
We present a scaling formula for size-dependent viscosity coefficients for proteins, polymers,
and fluorescent dyes diffusing in complex liquids. The formula was used to analyze the …

[HTML][HTML] Single-particle tracking as a quantitative microscopy-based approach to unravel cell entry mechanisms of viruses and pharmaceutical nanoparticles

N Ruthardt, DC Lamb, C Bräuchle - Molecular therapy, 2011 - cell.com
Highly sensitive fluorescence microscopy techniques allow single nanoparticles to be
tracked during their uptake into living cells with high temporal and spatial resolution. From …

Inferring transient particle transport dynamics in live cells

N Monnier, Z Barry, HY Park, KC Su, Z Katz… - Nature …, 2015 - nature.com
Live-cell imaging and particle tracking provide rich information on mechanisms of
intracellular transport. However, trajectory analysis procedures to infer complex transport …