Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Resilience is the process that allows individuals to adapt to adverse conditions and recover
from them. This process is favored by individual qualities that have been amply studied in …

Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal
stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising …

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …

Background In the last few years, the effects of bioactive food components have received
much attention because of their beneficial effects including decreasing inflammation …

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the
incidence and economic burden of which is increasing each year. OxS triggers the …

Sirtuins are a vast family of histone deacetylases, which are NAD+ dependent enzymes,
consisting of seven members, namely SIRT 1, SIRT 6 and SIRT 7 located within the nucleus …

Impaired nutrient sensing mechanisms such as AMPK/silent information regulator type 1
(SIRT1) axis and autophagy in renal cells upon chronic diabetic condition accelerate renal …

Background The annual incidence of diabetic foot ulcers (DFUs) has been reported to vary
from 0.2% to 11% in diabetes-specific clinical settings and less than 0.1% to 8% in …