[HTML][HTML] Recent preclinical and clinical progress in liposomal doxorubicin

K Aloss, P Hamar - Pharmaceutics, 2023 - mdpi.com
Doxorubicin (DOX) is a potent anti-cancer agent that has garnered great interest in research
due to its high efficacy despite dose-limiting toxicities. Several strategies have been …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

AC Marques, PJ Costa, S Velho, MH Amaral - Journal of controlled release, 2020 - Elsevier
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Modulating tumor hypoxia by nanomedicine for effective cancer therapy

R Jahanban‐Esfahlan, M de la Guardia… - Journal of cellular …, 2018 - Wiley Online Library
Hypoxia, a characteristic feature of tumors, is indispensable to tumor angiogenesis,
metastasis, and multi drug resistance. Hypoxic avascular regions, deeply embedded inside …

Lipid nanoparticles functionalized with antibodies for anticancer drug therapy

AC Marques, PC Costa, S Velho, MH Amaral - Pharmaceutics, 2023 - mdpi.com
Nanotechnology takes the lead in providing new therapeutic options for cancer patients. In
the last decades, lipid-based nanoparticles—solid lipid nanoparticles (SLNs) …

Direct inhibition of IRF-dependent transcriptional regulatory mechanisms associated with disease

A Antonczyk, B Krist, M Sajek, A Michalska… - Frontiers in …, 2019 - frontiersin.org
Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …

An overview of antibody conjugated polymeric nanoparticles for breast cancer therapy

A Juan, FJ Cimas, I Bravo, A Pandiella, A Ocaña… - Pharmaceutics, 2020 - mdpi.com
Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating
cancer. Active targeting NPs can be generated by conjugation with ligands that bind …

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

TL Cuellar, D Barnes, C Nelson, J Tanguay… - Nucleic acids …, 2015 - academic.oup.com
Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi. By targeting
internalizing cell surface antigens, antibody–siRNA complexes provide a possible solution …

Antibody conjugation of nanoparticles as therapeutics for breast cancer treatment

A Juan, FJ Cimas, I Bravo, A Pandiella… - International journal of …, 2020 - mdpi.com
Breast cancer is the most common invasive tumor in women and the second leading cause
of cancer-related death. Nanomedicine raises high expectations for millions of patients as it …

Nanoparticles as a solution for eliminating the risk of mycotoxins

P Horky, S Skalickova, D Baholet, J Skladanka - Nanomaterials, 2018 - mdpi.com
Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The
occurrence of mycotoxins in food and feed causes negative health impacts on both humans …