The tumor stroma, a key component of the tumor microenvironment (TME), is a key
determinant of response and resistance to cancer treatment. The stromal cells, extracellular …

Globally, cancer is a major catastrophic disease that seriously threatens human health.
Thus, there is an urgent need to find new strategies to treat cancer. Among them, identifying …

Background The aberrant expression of stromal gene signatures in breast cancer has been
widely studied. However, the association of stromal gene signatures with tumor immunity …

The immune context of the tumor microenvironment (TME) is critical for effective
immunotherapy. Nonetheless, DNA-based biomarkers for the immune-sensitive TME and …

Tumor microenvironments are composed of a myriad of elements, both cellular (immune
cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular …

Simple Summary Chemotherapy is becoming an increasingly difficult antitumor therapy to
practice due to the multiple mechanisms of drug resistance. To overcome the problem, it is …

Hypoxia is a common feature of most solid tumors, which promotes the proliferation,
invasion, metastasis, and therapeutic resistance of tumors. Researchers have been …

Cancer is a leading cause of death worldwide. The burden of cancer incidence and mortality
is increasing rapidly. New approaches to cancer prevention and treatment are urgently …

Cancer is the primary cause of death in economically developed countries and the second
leading cause in developing countries. Colorectal cancer (CRC) is the third most common …

Prostate cancer (PCa) is one of the most prominent causes of cancer‑related mortality in the
male population. A highly impactful prognostic factor for patients diagnosed with PCa is the …